Ovulation induction with various hormonal agents has become a standard component of in vitro fertilization (IVF) cycles to obtain multiple oocytes. Among the advantages of controlled ovarian hyperstimulation are the increased numbers of oocytes
and
thus
embryos that are available for embryo trasnfer(ET) and the enhanced cycle control that is achievable, especially with the concurrent use of the gonadotropin-releasig hormone analogues(GnRHa). However, controlled ovarian hyperstimulation increases
the
cost of the cycle and including those with regular ovulaqtory cycles, do not respond to ovarian stimulatory drugs.
Recent communications have reported successful pregnancies after IVF in unstimulated cycles triggered with or without human chorionic gonadotropin(hCG).
In this study, our objections is to describe the clinical experience of our center with in vitro fertilization (IVF) in unstimulated cycles. We report our results in 67 patients, 96 cycles spontaneously ovulatory women with predominantly pelvic
and
tubal factor as their principal cause of infertility, under the age of 40, and no male factor.
In the ninty six spontaneously ovulatory cycles, sixty six follicle aspirated cycles( oocyte retrieval rate:68.8%) resulted in nine clinical pregnancies(18.4).
We conclude that favorable results can be obtained from the unstimulted IVF. The unstimulated IVF is the viable alternatives to gonadotropin stimulated cycles in some patients, with pregnancy rates approximatly oe half those of stimulated cycles.
It is
reasonable to offer patients up to three or more cycles of unstimulated IVF without expecting a decrease in pregnancy rates.
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